Effect of Cornus mas L. fruit extract on lipid accumulation product and cardiovascular indices in patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial

  • Abbas Ali Sangouni
    Affiliations
    Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Nutrition and Food Security Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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  • Zohreh Sadat Sangsefidi
    Affiliations
    Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Nutrition and Food Security Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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  • Faezeh Yarhosseini
    Affiliations
    Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Nutrition and Food Security Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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  • Mahdieh Hosseinzadeh
    Affiliations
    Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Nutrition and Food Security Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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  • Mohsen Akhondi-Meybodi
    Affiliations
    Gastroenterology Department, Shahid Sadoughi Hospital, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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  • Alimohammad Ranjbar
    Affiliations
    Department of Pharmacognosy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Herbal Medicine Center, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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  • Farzan Madadizadeh
    Affiliations
    Research Center of Prevention and Epidemiology of Non-Communicable Disease, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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  • Hassan Mozaffari-Khosravi
    Correspondence
    Corresponding author. Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
    Affiliations
    Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Nutrition and Food Security Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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Published:November 23, 2021DOI:https://doi.org/10.1016/j.clnesp.2021.11.023

      Summary

      Background & aims

      Non-alcoholic fatty liver disease (NAFLD) is associated with high risk of cardiovascular diseases. The experimental studies have suggested that Cornus mas L. (cornelian cherry) fruit can improve cardiovascular risk factors. We designed a study to investigate the effect of cornelian cherry fruit extract on cardiovascular outcomes in patients with NAFLD.

      Methods

      We conducted a double-blind, randomized controlled trial. Fifty patients with NAFLD were randomly assigned into the treatment and the control groups. The treatment group received 20 cc/d cornelian cherry fruit extract as liquid form and the control group received 20 cc/d placebo for 12 weeks. The primary outcomes included lipid accumulation product (LAP), atherogenic index of plasma (AIP), Castelli risk index I (CRI-I), CRI-II and atherogenic coefficient (AC).

      Results

      At the baseline, there was no significant difference between two groups in values of LAP, AIP, CRI-I, CRI-II and AC. After the intervention, no significant change was found in the treatment group compared to the control group in LAP (−0.64 (−6.25 to 8.29) vs. 0.0 (−8.66 to 19.01); P = 0.91), AIP (0.0 ± 0.08 vs. 0.0 ± 0.1; P = 0.84), CRI-I (−0.18 ± 0.63 vs. −0.31 ± 0.49; P = 0.42), CRI-II (−0.23 ± 0.56 vs. −0.15 ± 0.32; P = 0.52) and AC (−0.18 ± 0.63 vs. −0.31 ± 0.49; P = 0.42).

      Conclusion

      Cornelian cherry fruit extract has no effect on cardiovascular outcomes. Further studies with longer intervention durations are needed.

      Trial registration

      Registered on 30 September 2018 at Iranian Registry of Clinical Trials (IRCT20180419039359N1).

      Keywords

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