Milk intake increases bone mineral content through inhibiting bone resorption: Meta-analysis of randomized controlled trials

  • Author Footnotes
    c Contributed equally to the work; Wei Zheng is the Co-first author.
    De Fu Ma
    Correspondence
    Corresponding author. Tel.: +86 10 82801743; fax: +86 10 82802002.
    Footnotes
    c Contributed equally to the work; Wei Zheng is the Co-first author.
    Affiliations
    Department of Social Medicine & Health Education, School of Public Health, Peking University, Xueyuan Road 38, Haidian District, Beijing 100191, PR China
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  • Author Footnotes
    c Contributed equally to the work; Wei Zheng is the Co-first author.
    Wei Zheng
    Footnotes
    c Contributed equally to the work; Wei Zheng is the Co-first author.
    Affiliations
    Department of Nutrition & Food Hygiene, School of Public Health, Peking University, Beijing 100191, PR China
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  • Ming Ding
    Affiliations
    Department of Nutrition & Food Hygiene, School of Public Health, Peking University, Beijing 100191, PR China
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  • Yu Mei Zhang
    Affiliations
    Department of Nutrition & Food Hygiene, School of Public Health, Peking University, Beijing 100191, PR China
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  • Pei Yu Wang
    Affiliations
    Department of Social Medicine & Health Education, School of Public Health, Peking University, Xueyuan Road 38, Haidian District, Beijing 100191, PR China
    Search for articles by this author
  • Author Footnotes
    c Contributed equally to the work; Wei Zheng is the Co-first author.
Published:November 19, 2012DOI:https://doi.org/10.1016/j.clnme.2012.10.005

      Summary

      Background and aims

      To clarify the effects of milk intake on bone mineral density (BMD) ,bone mineral content (BMC) and bone metabolism markers.

      Methods

      We identified randomized controlled trials related to urinary N-telopeptide cross-links of type I collagen (NTx), serum osteocalcin, BMD and BMC listed on MEDLINE (January 1966–November 2010), Science Citation Index and PUBMED (updated till November 2010), China National Knowledge Infrastructure (1979–November 2010) etc.

      Results

      Eleven studies with a total of 2397 subjects were selected for meta-analysis. The osteocalcin in subjects who consumed milk decreased by 5.9 (95% confidence interval (CI) 7.23, 4.57) ng/ml in comparison to that in control treatment. Milk intake vs control treatment significantly decreased urine NTx by 5.41 (95% CI 10.35, 0.47) nmol/mmol. Moreover, the total body BMC in subjects who consumed milk increased significantly by 40.32 (95% CI 17.58, 63.05) g in comparison to that in control treatment. Milk intake vs control treatment increased total body BMD by 0.01 (95% CI -0.02, 0.03) g/cm2 with borderline significance.

      Conclusions

      Milk intervention significantly attenuates bone loss through inhibiting bone metabolism.

      Keywords

      Abbreviations:

      RCTs (randomized controlled trials), BMD (bone mineral density), BMC (bone mineral content), NTx (N-telopeptide cross links of type I collagen), MBP (milk basic protein)
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