Improvement of sperm quality after micronutrient supplementation

  • Martin Imhof
    Correspondence
    Corresponding author. Department of Obstetrics and Gynecology, General Public Teaching Hospital Korneuburg, Wiener Ring 3-5, A-2100 Korneuburg, Austria. Tel.: +43 2262 780 5750; fax: +43 2262 780 5618.
    Affiliations
    Fertility Clinic IMI, Dorotheergasse 7, A-1010 Vienna, Austria

    Department of Obstetrics and Gynecology, General Public Teaching Hospital Korneuburg, Wiener Ring 3-5, A 2100 Korneuburg, Vienna, Austria
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  • Jakob Lackner
    Affiliations
    Fertility Clinic IMI, Dorotheergasse 7, A-1010 Vienna, Austria

    Department of Urology, General Public Hospital Hietzing, Wolkersbergenstrasse 1, A-1130 Vienna, Austria
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  • Markus Lipovac
    Affiliations
    Fertility Clinic IMI, Dorotheergasse 7, A-1010 Vienna, Austria

    Department of Obstetrics and Gynecology, General Public Teaching Hospital Korneuburg, Wiener Ring 3-5, A 2100 Korneuburg, Vienna, Austria
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  • Peter Chedraui
    Affiliations
    Institute of Biomedicine, Universidad Católica de Santiago de Guayaquil, Av. Carlos J. Arosemena Km 1.5, Guayaquil, Ecuador
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  • Claus Riedl
    Affiliations
    Department of Urology, General Public Hospital Baden, Wimmergasse 19 A-2500 Baden, Austria
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Published:December 06, 2011DOI:https://doi.org/10.1016/j.eclnm.2011.11.002

      Summary

      Background & aims

      Nearly 50% of male infertility is idiopathic and to date there still is no proven therapy. We evaluated the effect of a non prescription nutraceutical containing eight micronutrients on sperm quality in males with idiopathic sub-fertility.

      Methods

      This open comparative pilot study was carried out at the Fertility Center IMI, Vienna, Austria. A total of 132 sub-fertile males (active treatment group) were invited to participate and take two daily capsules of the active compound for a three month period between the first and the follow-up semen analysis. Each capsule contained L-carnitine, L-arginine, zinc, vitamin E, glutathione, selenium, coenzyme Q10 and folic acid. Sub-fertile men receiving no active treatment served as controls (n = 73). Main outcome measure was the standardized semen analysis.

      Results

      All parameters evaluated by semen analysis significantly increased after 3 months of treatment with the active compound. Median ejaculatory volume, sperm cell density, sperm motility (progressive and total) and normal morphology rate increased by 33.3%, 215.5%, 83.1%, 36.4% and 23.0%, respectively. These increments were significantly higher than those observed among controls. In the active treatment group no side effects were encountered and a total of 34 pregnancies were reported after 6 months follow-up whereas 11 were reported in the control group.

      Conclusion

      Semen analysis significantly improved in sub-fertile men after treatment with an active micronutrient compound, leading to pregnancies without any adverse effects.

      Keywords

      Abbreviations:

      WHO (World Health Organization), NO (nitric oxide), CoQ10 (coenzyme Q10), ATP (adenosine triphosphate), DNA (deoxyribonucleic acid)
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